Ingredients

Dermisil for Nail Infection is made from 100% pure plant extracts. The active components of Dermisil for Nail Infection are high levels of alpha-terpinene-4-ol, and cineol, both compounds found in the plant extracts cymbopogon citratus, melaleuca alternifolia, and two additional powerful anti-fungal extracts, that have well proven properties shown to be highly effective in combating these fungal conditions and their complications.

The topical application of these extracts is lipophilic. The extracts absorb into and underneath your skin as soon as they are applied. We travel the world in search of only certified plant extracts that are pesticide-free and United States Pharmaceutical Grade.

Active ingredients in Dermisil for Nail Infection are: cymbopogon citratus, melaleuca alternifolia, and two additional powerful anti-fungal plant extracts.

Medical Studies

Antifungal activity of the components of Melaleuca alternifolia.

Hammer KA, Carson CF, Riley TV.

Discipline of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA, Australia. khammer@cyllene.uwa.edu.au

AIMS: To investigate the in vitro antifungal activity of the components of Melaleuca alternifolia oil (an active ingredient of Dermisil for Nail Infection). METHODS AND RESULTS: Activity was investigated by broth microdilution and macrodilution, and time kill methods. Components showing the most activity, with minimum inhibitory concentrations and minimum fungicidal concentrations of < or =0.25%, were terpinen-4-ol, alpha-terpineol, linalool, alpha-pinene and beta-pinene, followed by 1,8-cineole. The remaining components showed slightly less activity and had values ranging from 0.5 to 2%, with the exception of beta-myrcene which showed no detectable activity. Susceptibility data generated for several of the least water-soluble components were two or more dilutions lower by macrodilution, compared with microdilution. CONCLUSIONS: All Melaleuca Alternifolia components, except beta-myrcene, had antifungal activity. The lack of activity reported for some components by microdilution may be due to these components becoming absorbed into the polystyrene of the microtitre tray. This indicates that plastics are unsuitable as assay vessels for tests with these or similar components. SIGNIFICANCE AND IMPACT OF THE STUDY: This study has identified that most components of Melaleuca Alternifolia have activity against a range of fungi. However, the measurement of antifungal activity may be significantly influenced by the test method.

PMID: 12969301 [PubMed - indexed for MEDLINE]

Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials.

Martin KW, Ernst E.

Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK.

Traditional medicine has made use of many different plant extracts for treatment of fungal infections and some of these have been tested for in vitro antifungal activity. This systematic review evaluates antifungal herbal preparations that have been tested in controlled clinical trials. Four electronic databases were searched for controlled clinical trials of antifungal herbal medicines. Data were extracted in a standardized manner by two independent reviewers and are reviewed narratively. Seven clinical trials met our inclusion criteria. Melaleuca Alternifolia preparations were tested in four randomized clinical trials and some positive outcomes were attributed to the intervention in all trials. Solanum species (two trials) and oil of bitter orange preparations (one trial) were compared with conventional treatments. In all cases encouraging results were reported. There are few controlled clinical trials of herbal antifungal medicines. The most thoroughly clinically tested is Melaleuca Alternifolia, which holds some promise. All herbal remedies require further investigation in rigorous clinical trials.

PMID: 15078424 [PubMed - indexed for MEDLINE]

Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia plant extract in cream.

Syed TA, Qureshi ZA, Ali SM, Ahmad S, Ahmad SA.

Department of Dermatology, University of California, San Francisco, USA. tasyed@itsa.ucsf.edu

The prevalence of onychomycosis, a superficial fungal infection that destroys the entire nail unit, is rising, with no satisfactory cure. The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil (an active ingredient in Dermisil forNail Infection) incorporated in a cream to manage toenail onychomycosis in a cohort. Sixty outpatients (39 M, 21 F) aged 18-80 years (mean 29.6) with 6-36 months duration of disease were randomized to two groups (40 and 20), active and placebo. After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group. Four patients in the active treatment group experienced subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurred in cured patients and no improvement was seen in medication-resistant and placebo participants.

PMID: 10357864 [PubMed - indexed for MEDLINE]